Persufflation 101: Breathing Life into Donor Organs Before Transplantation

Persufflation may be unfamiliar to many, but its concept is both simple and powerful. Instead of relying solely on cold storage, persufflation involves gently flowing oxygen (or other gases) through an organ’s vascular network during preservation.

This technique actively supports cell metabolism, prevents hypoxic damage, and maintains tissue integrity. When combined with controlled hypothermia, persufflation creates a low-stress environment that enhances organ viability.

Initial research and preclinical trials suggest significant improvements in post-transplant function. For transplant professionals, persufflation is a tool that could transform how we prepare organs—and how well those organs perform after transplantation.