Publications
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Persufflation - Current State of Play
With the ever-increasing disparity between the number of patients waiting for organ transplants and the number organs available, some patients are unable to receive life-saving transplantation in time….
Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling
All human islets used in research and for the clinical treatment of diabetes are subject to ischemic damage during pancreas procurement, preservation, and islet isolation. A major factor influencing islet function is exposure of pancreata to cold ischemia during unavoidable windows of preservation by static cold storage (SCS). Improved preservation methods may prevent this functional deterioration..
Persufflation (or gaseous oxygen perfusion) as a method of organ preservation
Improved preservation techniques have the potential to improve transplant outcomes by better maintaining donor organ quality and by making more organs available for allotransplantation. Persufflation, (PSF, gaseous oxygen perfusion) is potentially one such technique that has been studied for over a century in a variety of tissues, but has yet to gain wide acceptance for a number of reasons..
Understanding pancreas-machine interactions during preservation: A mathematical approach
Understanding of the pancreas is impacted by its fragility. This in part has led to the under-utilisation of pancreata for transplantation. Gaseous oxygen perfusion (persufflation) is a technique which has shown promise in improving pancreas preservation…
Persufflation Improves Pancreas Preservation When Compared With the Two-Layer Method (TLM)
Islet transplantation is emerging as a promising treatment for patients with type 1 diabetes. It is important to maximize viable islet yield for each organ due to scarcity of suitable human donor pancreata, high cost, and the large dose of islets required for insulin independence. However, organ transport for 8 hours using the two-layer method (TLM) frequently results in low islet yields. Since efficient oxygenation of the core of larger organs (eg, pig, human) in TLM has recently come under question, we investigated oxygen persufflation as an alternative way to supply the pancreas with oxygen during preservation...
SmartAudits: Applying Timebands to a Medical Device
The logistics of advanced organ preservation techniques are taxing: medical devices either require constant trained-monitoring or provide support for transplant decisions.…
Pancreas Oxygen Persufflation Increases ATP Levels as Shown by NMR
Islet transplantation is a promising treatment for type 1 diabetes. Due to a shortage of suitable human pancreata, high cost, and the large dose of islets presently required for long-term diabetes reversal; it is important to maximize viable islet yield. Traditional methods of pancreas preservation have been identified as suboptimal due to insufficient oxygenation. Enhanced oxygen delivery is a key area of improvement....