Reimagining Organ Preservation: The Promise of Hypothermic Temperature Control and Persufflation

In the rapidly evolving field of organ transplantation, the condition of the donor organ at the time of transplant is as critical as the procedure itself. For decades, static cold storage has been the standard for organ preservation. While simple and cost-effective, it has major limitations—primarily, it slows but does not stop metabolic activity, leaving organs vulnerable to ischemic injury.

Our solution combines precise hypothermic temperature control with persufflation, a method that delivers oxygen directly through the organ’s vasculature. Hypothermia reduces the metabolic rate, while persufflation keeps cells viable by supporting their oxygen needs.

Together, these approaches create a dynamic preservation environment that minimizes tissue damage and maximizes transplant success. This method has the potential to extend organ viability, improve graft function, and increase access to life-saving transplants worldwide.